WebDec 26, 2001 · Objective: To examine the specificity of low CSF hypocretin-1 levels in narcolepsy and explore the potential role of hypocretins in other neurologic disorders. Methods: A method to measure hypocretin-1 in 100 μL of crude CSF sample was established and validated. CSF hypocretin-1 was measured in 42 narcolepsy patients … WebHypocretin/Orexin. Indication Suspected narcolepsy. Method RIA Response Quantitative analysis of cerebrospinal fluid where the detection limit is 10 pg/ml. Interpretation Hypocretin-1 levels are usually significantly reduced in individuals that have narcolepsy with cataplexy. The reason for the low hopycretin-1 levels is believed to be due to ...
Considerably Lower Levels of Hypocretin-1 in Cerebrospinal Fluid …
WebMar 7, 2024 · CSF hypocretin-1 levels and electronic health records were available for 355 individuals. Cataplexy characteristics were available for 271 of them. As shown in Figure 1, 342 out of 355 individuals (96.3%) were categorized with the clinical diagnosis NT1, NT2, familial narcolepsy, idiopathic hypersomnia, or “other.” The remaining 13 ... WebThis demonstrated normal architecture without pathology (Table 1). The mean sleep latency (MSL) for five naps was 1.3 minutes with sleeponset rapid eye movement (REM) periods (SOREMPs) in all five nap periods (Table 2). HLA-typing and a CSF hypocretin level were not performed due to her classic presentation and reported cataplectic symptoms. howard guest house germiston
About Narcolepsy Center for Narcolepsy Stanford Medicine
WebHighlights. Orexin-A (hypocretin-1) is a neuropeptide involved in the sleep/wake cycle in humans. An abnormally low concentration of orexin-A (hypocretin-1) in cerebrospinal … Web: mayocliniclabs.com: Email: [email protected]: Telephone: 800-533 … WebResults: In sum, 19 patients (66%) had a CSF hypocretin-1 level <110 pg/ml, of whom two had current severe depression without any features of narcolepsy except EDS. The … WebAug 3, 2024 · The autoimmune model of narcolepsy inspired trials of intravenous (IV) immunoglobulin (IVIG) therapy in narcoleptic patients with low levels of hypocretin-1. In … how many in in a mile