WebEquation 2a is the modified Cheng-Prusoff equation, where the values that stood for the radioligand were substituted for the nonradiolabeled ligand and vice versa. Equation 2b is a rearrangement ... WebIn this situation, the Cheng-Prusoff equation results in erroneous predictions. The objective of this paper is to estimate the kinetic parameters K I and k inact directly from time- dependent IC50 ...

Cheng-Prusoff relationship - Big Chemical Encyclopedia

IC50（アイシーフィフティ）、50%阻害濃度（50パーセントそがいのうど）または半数阻害濃度（はんすうそがいのうど）とは、化合物の生物学的または生化学的阻害作用の有効度を示す値である。どの濃度で、その薬物（毒など）が標的としている物の半数（50％）の働きを阻害できるかを示す。 WebThe Cheng-Prusoff equation is Ki = IC50/ (1+ [S]/Km) where, Ki = the inhibitory constant, defined as the equilibrium concentration of an inhibitory ligand when 50% of the receptor sites are occupied if no competing … consumo lavatrice watt

William Prusoff - Wikipedia

WebThe lower the IC50 or K, the higher the affinity. Results can also be expressed as a K, the inhibitory (or affinity) constant of the displacer compound for the receptor. and IC50 are not independent and are very simply related when the displacement is non-competitive (/T = IC50), but the relationship becomes more complicated ( Cheng-Prusoff ... WebApr 9, 1985 · Crenshaw was No. 3 on the PGA Tour in its five-year putting statistics, taking an average of 28.97 per round. He is currently 134th, taking an average of 30.50. Slump … WebMar 1, 1993 · Using the Cheng–Prussoff relationship [13], Ki values for inhibition of FMLP, LTB4 and PAF were 1.33 × 10−10 M, 1.34 × 10−10 M and 2.53 × 10−9 M, respectively. Experiments were carried out on neutrophils incubated with the potent NADPH oxidase inhibitors DPI [14] and apocynin [15] prior to stimulation of [Ca2+]i responses with FMLP ... consumo kicks 2023